Protein Molecular Weight Markers
ABclonal Technology TLK1 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RAB1A Rabbit pAb
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms.
ABclonal Technology SYT1 Rabbit pAb
This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome.
ABclonal Technology PEN2/PSENEN Rabbit pAb
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimers disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
ABclonal Technology eEF2 Rabbit mAb
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
Biolegend Prime-Step™ Prestained Broad Range Protein Ladder
Prime-Step™ Prestained Broad Range Protein Ladder Apps: WB; Size: 50 uL
ABclonal Technology Carbonic Anhydrase 2 (CA2) Rabbit pAb
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology PLA2G4A Rabbit pAb
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants.
ABclonal Technology VILL Rabbit pAb
The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling.
New England Biolabs, Inc. Unstained Protein Standard, Broad Range – 750 gel lanes
The Unstained Protein Standard, Broad Range is a mixture of highly pure, recombinant proteins that resolves into 13 sharp bands from 10-200 kDa when electrophoresed and stained with Coomassie Brilliant Blue R-250 or other commercially available, ready-to-use protein stains.
ABclonal Technology Rad23B Rabbit pAb
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
ABclonal Technology SPC25 Rabbit pAb
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.
ABclonal Technology LARS Rabbit pAb
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.
ABclonal Technology PSMC5 Rabbit pAb
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings made of 28 subunits, while the 19S regulator includes a base with ATPase subunits and a lid with non-ATPase subunits. Proteasomes, located throughout eukaryotic cells, cleave peptides in an ATP/ubiquitin-dependent process. The immunoproteasome processes class I MHC peptides. This gene encodes an ATPase subunit, part of the triple-A family of ATPases with chaperone-like activity. Beyond proteasome function, it may also participate in transcriptional regulation, interacting with thyroid hormone and retinoid X receptors. Two isoforms of this gene are produced by alternative splicing.
ABclonal Technology CTRB1 Rabbit pAb
This gene encodes a serine protease that is a precursor of pancreatic proteolytic enzymes. The preproprotein is synthesized in the pancreas and secreted into the small intestine, where it is activated to form the functional enzyme. The CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have a haplotype with a 16.6 Kb inversion region, swapping portions of intron 1, exon 1, and upstream sequences between CTRB1 and CTRB2. This inversion is linked to differential gene expression and an increased risk of chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 in CTRB1. SNP rs8048956 in intron 1 of CTRB2 is diagnostic for the inversion. The CTRB1 gene encodes distinct isoforms, which may undergo similar processing to generate the mature protein.